Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI2C2)

Applications and Tested Dilutions

Product Specifications

Target Information

The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enzymes have been linked to diverse receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases are involved in signaling pathways related to cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.

This protein contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. It can be activated by insulin and may be involved in integrin-dependent signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.