Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI2C2)
PIK3C2A 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체. Western blot 및 IHC(P)에서 검증됨. 인간 시료에 반응하며, IgG1 아이소타입. 액상 형태로 제공되며 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 230–560 of PIK3C2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725024 |
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enzymes have been linked to diverse receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. PI3-kinases are involved in signaling pathways related to cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. It can be activated by insulin and may be involved in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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