Thermo Fisher Scientific TNFRSF21 Monoclonal Antibody (8H6)
인간 TNFRSF21(Death Receptor 6, DR6)을 인식하는 mouse monoclonal antibody (clone 8H6). ELISA에 최적화된 시약으로, 비결합형 액상 형태이며 PBS buffer에 보존제 없이 제공. 연구용으로 apoptosis 및 TNF receptor 관련 연구에 적합.
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Applications
- ELISA (ELISA)
Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8H6 |
| Immunogen | TNFRSF21 (AAH17730.1, 89 a.a. approximately 170 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SSCPVGTFTR HENGIEKCHD CSQPCPWPMI EKLPCAALTD RECTCPPGMF QSNATCAPHT VCPVGWGVRK KGTETEDVRC KQ
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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