Thermo Fisher Scientific TNFRSF21 Monoclonal Antibody (6H8)
Human DR6(TNFRSF21)에 특이적인 Mouse monoclonal antibody(클론 6H8). ELISA에 적합하며, 비결합형 액상 형태로 제공. 친화 크로마토그래피로 정제되었으며 PBS(pH 7.4) 버퍼에 보존제 없이 저장. 연구용으로만 사용 가능.
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Applications
- ELISA (ELISA): Tested dilution 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H8 |
| Immunogen | TNFRSF21 (AAH17730.1, 89 a.a. ~ 170 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SSCPVGTFTR HENGIEKCHD CSQPCPWPMI EKLPCAALTD RECTCPPGMF QSNATCAPHT VCPVGWGVRK KGTETEDVRC KQ
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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