Thermo Fisher Scientific PXR Polyclonal Antibody
Thermo Fisher Scientific의 PXR Polyclonal Antibody는 인간, 생쥐, 랫트 시료에 반응하며 WB, ICC/IF, ELISA, IP에 적합합니다. Affinity chromatography로 정제된 액상 항체로, PBS와 50% glycerol 버퍼에 보관되며 -20°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 400 µg–600 µg extracts |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 135–230 of human PXR (NP_0038803) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.87 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901346 |
Product Specific Information
- Positive Samples: Mouse liver, Rat kidney
- Immunogen Sequence:
TQPLGVQGLT EEQRMMIREL MDAQMKTFDT TFSHFKNFRL PGVLSSGCEL PESLQAPSRE EAAKWSQVRK DLCSLKVSLQ LRGEDGSVWN YKPPAD
Target Information
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR.
It is activated by compounds such as dexamethasone and rifampicin that induce CYP3A4. Several alternatively spliced transcripts encoding different isoforms have been described, some using non-AUG translation initiation codons. Additional transcript variants exist but have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-116715_PXR_O75469-1_Rabbit.svg, PA5-116715_PXR_O75469-1_Rabbit_PDP.jpeg)
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