Thermo Fisher Scientific ASIC1 Polyclonal Antibody
ASIC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 사용 가능. 인간 반응성, 고순도 Protein A 및 Antigen affinity 정제. 뇌 신경세포 연구 및 이온 채널 기능 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between amino acids 500–526 from the C-terminal region of human ACCN2 (ASIC1, UniProt ID: P78348-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543778 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, and rat based on sequence homology.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. These amiloride-sensitive sodium channels contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop rich in cysteine residues with conserved spacing.
ASIC1 is expressed broadly in brain neurons and may act as an ion channel subunit. It is a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampus, amygdala, cerebellum, and other brain regions.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-26278_ASIC1_P78348-2_Rabbit.svg, PA5-26278_ASIC1_P78348-2_Rabbit_PDP.jpeg)
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