Thermo Fisher Scientific ASIC1 Polyclonal Antibody
ASIC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, Flow Cytometry에 사용 가능. 인간 반응성, 고순도 Protein A 및 Antigen affinity 정제. 뇌 신경세포 연구 및 이온 채널 기능 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between amino acids 500–526 from the C-terminal region of human ACCN2 (ASIC1, UniProt ID: P78348-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543778 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, and rat based on sequence homology.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. These amiloride-sensitive sodium channels contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop rich in cysteine residues with conserved spacing.
ASIC1 is expressed broadly in brain neurons and may act as an ion channel subunit. It is a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampus, amygdala, cerebellum, and other brain regions.
Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-26278_ASIC1_P78348-2_Rabbit.svg, PA5-26278_ASIC1_P78348-2_Rabbit_PDP.jpeg)
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