Thermo Fisher Scientific Azurocidin Monoclonal Antibody (C5)
인간 Azurocidin 단백질을 인식하는 Mouse monoclonal antibody (Clone C5). Western blot, IHC(P), ICC/IF에 적합하며, 단백질 A/G로 정제된 액상형 항체. PBS(50% glycerol) 저장용액에 포함되어 있으며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C5 |
| Immunogen | Recombinant Human AZU protein, Pro23–Gly247 (Accession #P20160) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091138 |
Target Information
Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially, it was thought to have activity only against gram-negative bacteria, but later it was also found to act against gram-positive bacteria and C. albicans.
Azurocidin is a member of the antimicrobial protein family derived from polymorphonuclear leukocytes, including defensins, LL-37, and lysozyme. It plays a role in immune system activation and modulation, acting as an alarm signal. The cationic domain of the protein is essential for its antimicrobial activity.
Stored in azurophil and secretory granules, azurocidin is released early during extravasation. It is involved in chemotaxis and activation of monocytes, cytokine release, and phagocytosis, aiding efficient bacterial clearance. Its primary targets are endothelial cells and the extravascular environment. Interaction with leukocytes occurs via beta 2-integrins. Elevated plasma levels of azurocidin may help identify patients at risk of developing sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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