Thermo Fisher Scientific CCBL1 Polyclonal Antibody
Human CCBL1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 적합합니다. Antigen affinity chromatography로 정제되었으며, PBS 기반 buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCBL1. Recombinant protein control fragment (Product #RP-93062). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639344 |
Product Specific Information
Immunogen sequence:
LITDISDFKR KMPDLPGAVD EPYDRRFVKW MIKNKGLVAI PVSIFYSVPH QKHFDHYIRF CFVKDEATLQ AMDEKLRKWK VEL
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 78%
- Rat: 82%
Target Information
Kynurenine aminotransferases (KAT I, KAT II, and KAT III) belong to the class-I pyridoxal-phosphate-dependent aminotransferase family.
KAT I is a cytoplasmic protein involved in glutamine catabolism and catalyzes the transamination of L-kynurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan.
Kynurenic acid participates in synaptic transmission and is implicated in neurological disorders such as schizophrenia and Huntington’s disease.
KAT I also functions in the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes to produce reactive metabolites.
KAT I has three isoforms:
- Isoform 1: full length protein
- Isoform 2: lacks amino acids 68–117
- Isoform 3: lacks amino acids 251–422
Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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