Thermo Fisher Scientific PD-L1 Monoclonal Antibody (UMAB229), UltraMAB
PD-L1 단백질을 표적하는 UMAB229 단클론 항체로, 인간 시료에 반응하며 WB 및 IHC(P) 실험에 적합합니다. 동결건조 형태로 제공되며, 친화 크로마토그래피로 정제되었습니다. 종양 면역 회피 연구 및 PD-1/PD-L1 경로 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB229 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–290 of human CD274 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also known as B7-H1) is a member of the B7 family. It binds to its receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling. Upon binding, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be further upregulated by IFN-gamma stimulation. Therefore, PD-L1 plays an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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