Thermo Fisher Scientific IL1F9 Monoclonal Antibody (OTI2F4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IL1F9 (also known as IL-36γ) is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor, activating NF-κB and MAPK pathways in target cells.
It participates in epithelial barrier inflammatory responses, acting on keratinocytes, dendritic cells, and T-cells to promote tissue infiltration and cell proliferation.
In keratinocytes, IL1F9 induces expression of chemokines such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20, and CXCL1, and stimulates proinflammatory markers including TNF-α, S100A7 (psoriasin), and inducible NOS.
It may also play roles in neutrophilic airway inflammation and innate immune responses to fungal pathogens such as Aspergillus fumigatus.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.