Thermo Fisher Scientific Phospho-TAK1 (Thr187) Polyclonal Antibody
Phospho-TAK1 (Thr187) 항체로 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC, ELISA에 적합하며, 항원 친화 크로마토그래피로 정제된 rabbit polyclonal IgG입니다. TAK1 신호전달 연구에 유용한 연구용 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TAK1 around the phosphorylation site of Thr187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610279 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, it interacts with TGF-β receptor and TRAF6 to regulate activation of JNK and p38. TAK1 also participates in Wnt, BMP, activin, and other stress-related signaling pathways. It contributes to wound healing through regulation of PDGF-B and integrins, plays a critical role in IKK activation in IL-1, IL-6, TNF, and TLR pathways, and influences cell lifespan by repressing telomerase reverse transcriptase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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