Thermo Fisher Scientific LAP2 Polyclonal Antibody
LAP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 연구용으로만 사용.
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- PA5114460
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카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Thymopoietin antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human Thymopoietin. The immunogen is located within amino acids 80–130 of Thymopoietin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890396 |
Product Specific Information
Positive controls that may be used include: HeLa Cell Lysate, HeLa Cell Slide.
Target Information
In eukaryotic cells, the nuclear envelope consists of inner and outer membranes defining the border between the nucleus and cytoplasm. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. Lamins attach to the inner nuclear membrane through association with Lamin Associated Polypeptides (LAPs).
LAP 1A, 1B, and 1C share sequence homology, while LAP 2 is distinct. LAP 1A/B bind lamins A, C, and B1, while LAP 2 binds lamin B1 only. LAP 2 also binds chromosomes, and its phosphorylation during mitosis inhibits binding to both lamins and chromosomes, suggesting its role in nuclear envelope re-assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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