Thermo Fisher Scientific IGF1R (CD221) Recombinant Rabbit Monoclonal Antibody (012)
Recombinant rabbit monoclonal antibody specific for human IGF1R/CD221. Suitable for ICC/IF and flow cytometry. High purity (Protein A) and concentration (1 mg/mL). Stored at -20°C in PBS without preservative. For research use only.
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Thermo Fisher Scientific IGF1R (CD221) Recombinant Rabbit Monoclonal Antibody (Clone 012)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| Flow Cytometry (Flow) | 1:25–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 012 |
| Immunogen | Recombinant Human IGF1R/CD221 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912248 |
Additional Formats
Product Specific Information
Specificity: Human IGF1R/CD221
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2, implicated in various cancers. The protein forms a tetramer with two alpha and two beta subunits. The alpha subunits bind IGF-1 with higher affinity than IGF-2. Binding induces a conformational change and autophosphorylation at positions 1134, 1135, and 1136. Activated IGF1R phosphorylates substrate proteins, triggering RAS, RAF, and MAPK pathways (ERK, p38, JNK), leading to gene transcription and cell proliferation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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