Thermo Fisher Scientific ABCD4 Polyclonal Antibody
ABCD4 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며 인간 및 생쥐 시료에 반응. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ABCD4 (Accession O14678), corresponding to amino acid residues R112–S162 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850881 |
Product Specific Information
Antibody detects endogenous levels of total ABCD4.
Target Information
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1–4, that are known to be present in the human peroxisome membrane. All four proteins are ABC half-transporters, which dimerize to form an active transporter.
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder affecting lipid storage.
ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD.
The peroxisomal membrane comprises two major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles which may be defective peroxisomes or peroxisome precursors. ABCD1 localizes to peroxisomes. ABCB7 is a half-transporter involved in the transport of heme from mitochondria to cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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