Thermo Fisher Scientific SLC4A4 Polyclonal Antibody
SLC4A4 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 사용 가능하며, 인간·마우스·랫트 반응성. 고순도 친화 크로마토그래피 정제, PBS/glycerol 저장 용액. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC4A4 (Accession Q9Y6R1), corresponding to amino acid residues D1010–D1060 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852125 |
Product Specific Information
Antibody detects endogenous levels of total SLC4A4.
Target Information
Slc4a4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH.
It is an electrogenic sodium/bicarbonate cotransporter with Na(+):HCO3(−) stoichiometry varying from 1:2 to 1:3.
Slc4a4 may regulate bicarbonate influx/efflux at the basolateral membrane and intracellular pH.
Isoform 2 may have higher activity than isoform 1.
Mutations in Slc4a4 are associated with proximal renal tubular acidosis.
Multiple transcript variants encoding different isoforms have been found for the Slc4a4 gene.
Diseases associated with SLC4A4 include Renal Tubular Acidosis, Proximal, With Ocular Abnormalities, and Proximal Renal Tubular Acidosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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