Thermo Fisher Scientific Phospho-CFTR (Ser737) Polyclonal Antibody
CFTR 단백질의 Ser737 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 실험에 적합. Human, Mouse, Rat 시료 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CFTR (Accession P13569), corresponding to amino acid residues around phosphorylated Ser737 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817183 |
Product Specific Information
This antibody detects endogenous levels of CFTR only when phosphorylated at Ser737.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport. Despite its lethality, the CF mutation remains prevalent, possibly because Salmonella typhi uses CFTR to enter intestinal epithelial cells, and ΔF508 heterozygote and homozygote mice show 86% and 100% reductions in S. typhi intestinal submucosal uptake, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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