Thermo Fisher Scientific PNN Polyclonal Antibody
PNN 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도 PBS buffer에 보관됩니다. 인간 단백질 반응성으로 연구용에 최적화된 항체입니다.
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Thermo Fisher Scientific PNN Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PNN. Recombinant protein control fragment (Product #RP-88923). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645719 |
Product Specific Information
Immunogen sequence:
EQKVELAQLQ EEWNEHNAKI IKYIRTKTKP HLFYIPGRMC PATQKLIEES QRKMNALFEG RRIEFAEQIN KMEARPRRQS MKEKEHQVVR NEEQKAEQEE GKVAQREEEL EETGNQHNDV EIEEAGEEEE KEIAIVHSDA EKE
Highest antigen sequence identity:
- Mouse: 98%
- Rat: 97%
Target Information
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene (5CAGGTG-3). Capable of reversing CTBP1-mediated transcription repression.
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex transiently during mRNA metabolism.
Participates in regulation of alternative pre-mRNA splicing and associates to spliced mRNA within 60 nt upstream of the 5`-splice sites.
Component of the PSAP complex which binds RNA in a sequence-independent manner and regulates specific intron excision in transcription subsets.
Involved in epithelial cell-cell adhesion and acts as a potential tumor suppressor in renal cell carcinoma.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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