Thermo Fisher Scientific CNOT4 Monoclonal Antibody (OTI3B8), TrueMAB
CNOT4 단백질을 인식하는 Mouse monoclonal antibody로, Western blot에 최적화되어 있습니다. Human CNOT4(aa190-455) 항원으로 제작되었으며, Lyophilized 형태로 제공됩니다. 연구용으로만 사용 가능하며, 단백질 발현 및 전사 조절 연구에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 190–455 of human CNOT4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity involved in protein modification and ubiquitination.
It contains:
- A C4C4-type RING zinc finger domain
- An RNA recognition motif
- A bipartite nuclear localization signal
CNOT4 is a component of the CCR4-NOT (CAF1) complex, which regulates transcription both positively and negatively, controlling gene expression.
It interacts with CNOT1 via its C-terminus and with E2 ubiquitin ligases via its C4C4 RING domain.
Reports indicate that CNOT4 is phosphorylated in response to DNA damage at ATM/ATR consensus sites.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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