Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Polyclonal Antibody
Phospho-PDPK1 (Ser241)을 인식하는 Rabbit Polyclonal Antibody로, Western blot, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태로 -20°C 보관. 세포막 및 세포질 내 PDPK1 인산화 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S241 of human PDK1/PDPK1 (NP_002604.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.57 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914850 |
Product Specific Information
- Positive test controls include: NIH/3T3
- Target localization: Cell junction, Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, Focal adhesion
- Immunogen sequence: ANSFV
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1)
PDPK1은 AGC kinase를 인산화하며, conventional PKC 및 PKC zeta를 활성화합니다. 또한 phosphatidylinositol-3,4,5-trisphosphate 존재 하에서 Protein Kinase B (PKB)를 Thr308 잔기에서 인산화합니다. 활성화된 Akt는 Glycogen Synthase Kinase 3 (GSK3)를 불활성화시켜 glycogen synthase의 탈인산화 및 활성화를 유도하고, glycogen 합성을 촉진합니다.
PDPK1은 인슐린 유도 glycogen 합성과 PKC 활성화에 중요한 역할을 하므로, 대사성 약물 연구에서 잠재적으로 중요한 표적입니다.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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