Thermo Fisher Scientific CD335 (NKp46) Monoclonal Antibody (9E2), Super Bright 436, eBioscience
인간 CD335(NKp46)를 인식하는 9E2 클론 단일클론 항체로, Super Bright 436 형광체로 결합되어 유세포분석에 최적화됨. NK 세포 활성화 및 종양·바이러스 감염 세포 분석에 사용. 405 nm 레이저로 여기, 436 nm에서 방출. 4°C 암소 보관.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.25 µg)/test
- Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 436, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 9E2 |
| Conjugate | Super Bright™ 436 |
| Excitation / Emission Max | 413 / 431 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662245 |
Additional Available Formats
- Alexa Fluor 488
- APC
- eFluor 450
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 600
- Request custom conjugation
Product Specific Information
Description:
The 9E2 monoclonal antibody reacts with human CD335 (NKp46), a member of the natural cytotoxicity receptor family (including NKp30 and NKp44). CD335 is expressed on NK cells and plays a role in activating and expanding resting NK cells upon interaction with dendritic cells, enabling elimination of tumor and virus-infected cells (e.g., influenza). It also interacts with pancreatic beta cells during type I diabetes development.
The 9E2 antibody has been reported to induce cytotoxicity.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells.
Use 5 µL (0.25 µg) per test (defined as the amount that stains a cell sample in 100 µL final volume).
Cell number should be determined empirically (10⁵–10⁸ cells/test).
Fluorochrome Information:
Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm.
Recommended filter: 450/50 bandpass or equivalent. Ensure instrument compatibility.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
- Excitation: 405 nm
- Emission: 436 nm
- Laser: Violet Laser
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
NKp46 (CD335, NCR1) is a cytotoxicity-activating receptor that enhances the efficiency of activated NK cells in tumor cell lysis. It consists of two Ig-like domains related to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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