Thermo Fisher Scientific RICH2 Polyclonal Antibody
RICH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot, IHC, Flow cytometry에 적합합니다. Human에 반응하며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 784–811 amino acids from the C-terminal region of human RICH2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541652 |
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases, controlling their cycling between active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, it is involved in dendritic spine formation and synaptic plasticity with specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia and is recruited to actin-patches that seed filopodia. Binds specifically to plasma membrane sections deformed inward by acto-myosin mediated contractile forces. Through GAP activity on RAC1, it reduces actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated with long-term potentiation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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