Thermo Fisher Scientific NEFM Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is likely to react with most mammals.
Suggested positive control: antigen standard for NEFM (transient overexpression lysate).

Target Information

Neurofilaments (NFs) are intermediate filaments expressed almost exclusively in neuronal cells, particularly in large axons.
They are composed of three major subunits — NF-M (medium), NF-H (high), and NF-L (light) — which share a coiled-coil core domain but differ in the length and sequence of their termini.
The NF-M protein tail domain mediates neurofilament interactions critical for axonal size and cytoskeletal architecture.
Phosphorylation and O-GlcNAcylation of NF-M regulate its translocation, filament formation, and function.
Antibodies against neurofilament subunits serve as valuable neuronal markers due to their abundance, neuron-specific expression, and biochemical stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.