Thermo Fisher Scientific ATP6AP1 Monoclonal Antibody (3H11B12)
ATP6AP1 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody. Western blot, Flow cytometry, ELISA에 사용 가능. 인간 시료 반응성, Protein G 정제, 1 mg/mL 농도. 연구용으로 적합한 고품질 항체.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H11B12 |
| Immunogen | Purified recombinant fragment of human ATP6AP1 (AA: 51–151) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090933 |
Target Information
Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for the acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, synthesizing ATP in the process. The enzyme consists of a peripheral V1 domain (ATP hydrolysis) and an integral V0 domain (proton translocation).
ATP6AP1 (ATPase, H⁺ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1, or ATP6IP1, is a type I transmembrane V-ATPase accessory protein predominantly expressed in endocrine and neuronal cells. It is responsible for targeting the V-ATPase enzyme to specialized vacuolar systems and interacts with subunits of the V0 domain. Disruption of this interaction in osteoclasts results in impaired bone resorption, indicating its essential role in osteoclastic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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