Thermo Fisher Scientific ATP6AP1 Monoclonal Antibody (3H11B12)

Applications and Tested Dilutions

Product Specifications

Target Information

Vacuolar-type H⁺-ATPase (V-ATPase) is a multisubunit enzyme responsible for the acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, synthesizing ATP in the process. The enzyme consists of a peripheral V1 domain (ATP hydrolysis) and an integral V0 domain (proton translocation).
ATP6AP1 (ATPase, H⁺ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1, or ATP6IP1, is a type I transmembrane V-ATPase accessory protein predominantly expressed in endocrine and neuronal cells. It is responsible for targeting the V-ATPase enzyme to specialized vacuolar systems and interacts with subunits of the V0 domain. Disruption of this interaction in osteoclasts results in impaired bone resorption, indicating its essential role in osteoclastic function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.