Thermo Fisher Scientific UGGT1 Polyclonal Antibody
UGGT1 단백질을 표적으로 하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 Immunoprecipitation에 사용 가능. 인간 UGGT1의 1505–1555 영역을 면역원으로 제작. 액상 형태, 1 mg/mL 농도, 4°C 보관.
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Thermo Fisher Scientific UGGT1 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1505–1555 of Human UDP-glucose:glycoprotein glucosyltransferase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides.
UGGT transfers glucose from UDP-glucose to Man7–9GlcNAc2 moiety of unfolded glycoproteins in a Ca²⁺ dependent reaction.
It binds unfolded glycoproteins via two substrate elements: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids exposed in the denatured conformation.
UGGT is proposed to act as a sensor distinguishing folded and denatured proteins in the ER.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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