Thermo Fisher Scientific UGGT1 Polyclonal Antibody

Thermo Fisher Scientific UGGT1 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:2,000–1:10,000
• Immunoprecipitation (IP): 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides.
UGGT transfers glucose from UDP-glucose to Man7–9GlcNAc2 moiety of unfolded glycoproteins in a Ca²⁺ dependent reaction.
It binds unfolded glycoproteins via two substrate elements: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids exposed in the denatured conformation.
UGGT is proposed to act as a sensor distinguishing folded and denatured proteins in the ER.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.