Thermo Fisher Scientific UGGT1 Polyclonal Antibody
UGGT1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간과 생쥐 반응성을 가지며, 항원 친화 크로마토그래피로 정제된 액상 항체입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1505 to 1555 of Human UDP-glucose:glycoprotein glucosyltransferase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170 kDa lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides.
UGGT catalyzes the transfer of glucose from UDP-glucose to Man7–9GlcNAc2-moiety of unfolded glycoproteins in a Ca²⁺ dependent reaction.
UGGT binds unfolded glycoprotein via two substrate elements: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids exposed in the denatured conformation.
It is postulated that UGGT serves as a sensor distinguishing folded from denatured proteins in the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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