Thermo Fisher Scientific WDR5 Monoclonal Antibody (7B11)
인간 WDR5 단백질을 표적으로 하는 마우스 단클론 항체로 Western blot, ELISA, IHC 등 다양한 연구용으로 사용 가능. 정제된 재조합 WDR5 단백질을 면역원으로 제작되었으며, 비결합형 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 4 publications |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Pig |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7B11 |
| Immunogen | Purified recombinant fragment of human WDR5 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10977947 |
Product Specific Information
MA5-15664 targets WDR5 in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human WDR5 expressed in E. coli.
MA5-15664 detects WDR5, which has a predicted molecular weight of approximately 36.6 kDa.
Target Information
WDR5 is a cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
It acts as a molecular chaperone, localizing to genomic response elements in a hormone-dependent manner and disrupting receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes.
WDR5 also facilitates HIF alpha protein hydroxylation via interaction with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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