Thermo Fisher Scientific Torc1 Monoclonal Antibody (1B5)
Human CRTC1 단백질을 인식하는 mouse monoclonal antibody로 WB, ICC/IF, Flow Cytometry, ELISA에 적합합니다. 비결합형 액상 형태이며 4°C 단기, -20°C 장기 보관 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Torc1 Monoclonal Antibody (1B5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B5 |
| Immunogen | Purified recombinant fragment of human CRTC1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10980185 |
Product Specific Information
MA5-15666 targets CRTC1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human CRTC1 expressed in E. coli.
MA5-15666 detects CRTC1, which has a predicted molecular weight of approximately 67 kDa.
Target Information
CRTC1 is a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator in the SIK/TORC signaling pathway, active when dephosphorylated and independent of CREB1 Ser-133 phosphorylation.
CRTC1 enhances the interaction of CREB1 with TAF4 and regulates expression of CREB-activated genes such as StAR. It is a potent coactivator of PGC1α and induces mitochondrial biogenesis in muscle cells.
In the hippocampus, CRTC1 is involved in late-phase long-term potentiation (L-LTP) maintenance and may be required for dendritic growth of developing cortical neurons. Together with SIK1, it regulates light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1, crucial for photic entrainment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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