Thermo Fisher Scientific Torc1 Monoclonal Antibody (1B5)

Thermo Fisher Scientific Torc1 Monoclonal Antibody (1B5)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15666 targets CRTC1 in indirect ELISA, FACS, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human CRTC1 expressed in E. coli.
MA5-15666 detects CRTC1, which has a predicted molecular weight of approximately 67 kDa.

Target Information

CRTC1 is a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator in the SIK/TORC signaling pathway, active when dephosphorylated and independent of CREB1 Ser-133 phosphorylation.
CRTC1 enhances the interaction of CREB1 with TAF4 and regulates expression of CREB-activated genes such as StAR. It is a potent coactivator of PGC1α and induces mitochondrial biogenesis in muscle cells.
In the hippocampus, CRTC1 is involved in late-phase long-term potentiation (L-LTP) maintenance and may be required for dendritic growth of developing cortical neurons. Together with SIK1, it regulates light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1, crucial for photic entrainment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.