Thermo Fisher Scientific HLA Class 1 ABC (MHC I) Recombinant Rabbit Monoclonal Antibody (MHC-I/8366R)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MHC-I/8366R

Immunogen

Recombinant fragment (around aa100-300) of human HLA-I protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HLA-ABC,uniProtId:P04439-1,ncbiNodeId:9606,antigenRange:100-300,antigenLength:365,antigenImageFileName:RBM4-8366-P1ABX_HLA-ABC_P04439-1_Rabbit.svg,antigenImageFileNamePDP:RBM4-8366-P1ABX_HLA-ABC_P04439-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:HLA-ABC,uniProtId:P01889-1,ncbiNodeId:9606,antigenRange:100-300,antigenLength:362,antigenImageFileName:RBM4-8366-P1ABX_HLA-ABC_P01889-1_Rabbit.svg,antigenImageFileNamePDP:RBM4-8366-P1ABX_HLA-ABC_P01889-1_Rabbit_PDP.jpeg,sortOrder:2},{targetFamily:HLA-ABC,uniProtId:P10321-1,ncbiNodeId:9606,antigenRange:100-300,antigenLength:366,antigenImageFileName:RBM4-8366-P1ABX_HLA-ABC_P10321-1_Rabbit.svg,antigenImageFileNamePDP:RBM4-8366-P1ABX_HLA-ABC_P10321-1_Rabbit_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumor defense. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.