Thermo Fisher Scientific CLCN7 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CLCN7 protein. Validated for IHC and ICC/IF. Antigen affinity purified, supplied in PBS with glycerol. Suitable for research on chloride channel function and osteopetrosis-related studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CLCN7. Recombinant protein control fragment (Product #RP-98666). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639860 |
Product Specific Information
Immunogen sequence:
LRLKDFRDAY PRFPPIQSIH VSQDERECTM DLSEFMNPSP YTVPQEASLP RVFKLFRALG LRHLVVVDNR NQVVGLVT
Highest antigen sequence identity:
- Mouse: 99%
- Rat: 99%
Target Information
The CLCN7 gene encodes chloride channel 7, a member of the CLC chloride channel family. These channels are essential for chloride ion transport across plasma membranes and within intracellular organelles. Mutations in CLCN7 are associated with osteopetrosis autosomal recessive type 4 (OPTB4), also known as infantile malignant osteopetrosis type 2, and with autosomal dominant osteopetrosis type 2 (OPTA2), also called Albers-Schonberg disease or marble disease. Osteopetrosis is a rare genetic disorder characterized by abnormally dense bone due to defective bone resorption. OPTA2 typically manifests during adolescence or adulthood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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