Thermo Fisher Scientific Nhe-1 Polyclonal Antibody
Nhe-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB·IHC·ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상형 제품이며, 세포 내 pH 조절 연구에 적합.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide near the center of the human Nhe-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157890 |
Product Specific Information
- Suggested positive control: MOLT4 cell lysate
- PA5-20446 can be used with blocking peptide PEP-0563
Target Information
The Na⁺/H⁺ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by various signals including growth factors, mitogens, neurotransmitters, and tumor promoters.
Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton through structural links with actin-binding proteins ezrin, radixin, and moesin (ERM proteins).
A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton independent of its ion exchange function. It is also thought to play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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