Thermo Fisher Scientific CBX4 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human CBX4 protein. Validated for Western blot at 1:1,000 dilution. Predicted cross-reactivity with mouse. Suitable for studying Polycomb group proteins and DNA damage response mechanisms.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 410–437 amino acids from the C-terminal region of human CBX4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2071241 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified.
Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, and BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation.
Depletion of CBX4 results in decreased cellular resistance to ionizing radiation, indicating its role in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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