Thermo Fisher Scientific CASKIN1 Polyclonal Antibody
Human CASKIN1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관. 뇌 발달 및 시냅스 형성 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CASKIN1. Recombinant protein control fragment (Product #RP-101673). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639307 |
Product Specific Information
Immunogen sequence:
GKEQELVQAV KAEDVGTAQR LLQRPRPGKA KLLGSTKKIN VNFQDPDGFS A
Highest antigen sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity.
CASKINs (CASK interacting proteins) interact with CASK and are thought to play a role in CASK function by coupling CASK to distinct downstream effectors.
CASKIN1 is a multidomain protein containing six N-terminal ankyrin repeats, one SH3 domain, and two sterile alpha motif domains followed by a long proline-rich sequence and a short conserved C-terminal domain.
CASKIN1 coassembles with CASK on the cytoplasmic tail of neurexin 1, suggesting that CASKIN and CASK coat the cytoplasmic tails of neurexins and other cell-surface proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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