Thermo Fisher Scientific DCUN1D1 Polyclonal Antibody
DCUN1D1 단백질을 인식하는 Thermo Fisher Scientific의 산양 유래 polyclonal 항체입니다. Western blot과 IHC(Paraffin)에서 검증되었으며, 인간 시료에 반응합니다. 암모늄 황산 침전으로 정제되어 안정적이며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA519284
- 판매단위
- pk
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Thermo Fisher Scientific DCUN1D1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RPQIAGTKSTT) corresponding to the C-terminus amino acids of DCUN1D1 (aa 248–259) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10976834 |
Product Specific Information
- Predicted to react with bovine and mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
DCUN1D1 is part of an E3 ubiquitin ligase complex for neddylation. It promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation. This enhances recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester and optimizes protein orientation for efficient NEDD8 transfer. It also helps release inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. DCUN1D1 acts as an oncogene facilitating malignant transformation and carcinogenic progression.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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