Thermo Fisher Scientific RASSF1 Monoclonal Antibody (OTI8E4), TrueMAB
RASSF1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. Human recombinant RASSF1(aa 1-341)을 면역원으로 사용. 고순도 Affinity chromatography 정제, 액상 형태로 안정적 보관 가능.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8E4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1-341 of human RASSF1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of various cancers, suggesting its tumor suppressor function. Inactivation of this gene correlates with hypermethylation of its CpG-island promoter region. The encoded protein interacts with DNA repair protein XPA, inhibits accumulation of cyclin D1, and induces cell cycle arrest. Seven alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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