Thermo Fisher Scientific Phospho-c-Myc (Thr58, Ser62) Recombinant Rabbit Monoclonal Antibody (4E9)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2, and JNK is functionally associated with cell proliferation and regulation.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development. Deregulated expression of c-Myc induces apoptosis in various cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to targeted proteins.
Amplification of the c-Myc gene is found in lung, breast, and colon carcinomas, while N-Myc amplification is observed in neuroblastomas. Translocation of the c-Myc locus to immunoglobulin loci is described in Burkitt’s lymphoma and other B-cell lymphoproliferative conditions. Aberrant c-Myc expression occurs in tumors of multiple origins including colorectal, gastric, hepatic, mammary, ovarian, pulmonary, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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