Thermo Fisher Scientific JAK2 Recombinant Rabbit Monoclonal Antibody (18H11L8)
JAK2 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Expi293 시스템에서 발현되며 높은 특이성과 재현성을 제공합니다. 단백질 A로 정제되었으며, PBS 완충액에 보존됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 3 publications |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 18H11L8 |
| Immunogen | Peptide corresponding to Human JAK2 (aa 1004–1012) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4 °C short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633091 |
Product Specific Information
This antibody is predicted to react with Monkey, Rat, Sheep, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in Expi293 cells. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is frequently mutated in polycythemia vera. It contains the catalytic domain (JH1) responsible for kinase activity. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate gene transcription, including interferon-stimulated genes.
JAK2 is essential for IFN-γ receptor complex initiation, with JAK1 acting as an amplifier. Mutations in JAK2 are associated with disorders such as Budd–Chiari syndrome, Polycythemia vera, Thrombocythemia 3, Myelofibrosis, and Acute myelogenous leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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