Thermo Fisher Scientific ARNT Monoclonal Antibody (OTI1A1), TrueMAB
인간 ARNT(HIF-1 beta) 단백질을 표적으로 하는 Mouse IgG1 단클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry에 적합. 액상 형태로 제공되며 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific ARNT Monoclonal Antibody (OTI1A1), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A1 |
| Immunogen | Full length human recombinant protein of human ARNT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats:
Target Information
HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.
HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis, occurring via posttranslational modification by prolyl hydroxylation. It is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, while under hypoxic conditions, hydroxylation is inhibited, increasing transcriptional activity. HIF-1 beta remains stable under both conditions.
Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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