Thermo Fisher Scientific IL-1 alpha Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:5,000
• Tested in direct-ELISA

Product Specifications

Product Specific Information

This antibody has been tested in direct-ELISA.

Target Information

IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, which are shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and initiating acute-phase responses. Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding.
IL-1 alpha is involved in immune response, inflammation, and hematopoiesis, and can induce apoptosis following cell injury. It regulates NF-kappaB and MAPK pathways, and promotes expression of IL6, PTGS2 (COX-2), and nitric oxide production.
Elevated IL-1 alpha levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.