Thermo Fisher Scientific PAG1 Polyclonal Antibody
Human PAG1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 및 글리세롤 완충액에 보존. 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PAG1. Recombinant protein control fragment (Product #RP-102112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789120 |
Product Specific Information
Immunogen sequence:
PVPVKLLDEN ENLQEKEGGE AEESATDTTS ETNKRFSSLS YKSREEDPTL TEEEISAMYS SVNKPGQLVN KSGQSLTVPE STYTSIQGDP QRSPSSCNDL YATVKDFEKT PNSTLPPAG
Target Information
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which migrates on SDS PAGE gels as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and activates the protein tyrosine kinase Csk, a major negative regulator of Src family kinases.
Signaling via the B-cell receptor or high affinity IgE receptor (FcepsilonRI) leads to increased PAG phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding, and increased activation of Lck.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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