Thermo Fisher Scientific Phospho-TrkB (Tyr706, Tyr707) Polyclonal Antibody

Thermo Fisher Scientific Phospho-TrkB (Tyr706, Tyr707) Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100

Product Specifications

Product Specific Information

• A suggested positive control for IHC is human brain tissue.

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system.
NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is involved in the development and maintenance of the nervous system and is highly related to TrkA.
TrkB expression is confined to tissues within the central and peripheral nervous systems.
BDNF and NT-3 can induce rapid phosphorylation on tyrosine residues of TrkB gp145, with BDNF eliciting a stronger response.
TrkB is a membrane-bound receptor that phosphorylates itself and members of the MAPK pathway upon neurotrophin binding, leading to cell differentiation.
Mutations in the TrkB gene are associated with obesity and mood disorders.
Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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