Thermo Fisher Scientific Pepsinogen II Recombinant Rabbit Monoclonal Antibody (3M7P3)
Thermo Fisher Scientific의 Pepsinogen II Recombinant Rabbit Monoclonal Antibody (3M7P3)는 인간 Pepsinogen II를 인식하는 항체로, WB, IHC(P), ELISA에 적합합니다. 고순도 재조합 단일클론 항체로, HEK293 세포에서 발현되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3M7P3 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–388 of human Pepsinogen II (PG II) (NP_002621.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093023 |
Product Specific Information
Immunogen sequence:
MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP AWKYRFGDLS VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP SVYCQSQACT SHSRFNPSES STYSTNGQTF SLQYGSGSLT GFFGYDTLTV QSIQVPNQEF GLSENEPGTN FVYAQFDGIM GLAYPALSVD EATTAMQGMV QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY WAPVTQELYW QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT YLSSQNGQPL WILGDVFLRS YYSVYDLGNN RVGFATAA
Target Information
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme produced in the stomach and is a major component of the gastric mucosa. It is also secreted into the serum and synthesized as an inactive zymogen, which is converted into its active mature form at low pH by sequential cleavage of the prosegment.
Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases, including Helicobacter pylori-related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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