Thermo Fisher Scientific TNPO3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TNPO3. Recombinant protein control fragment (Product #RP-92622). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TNPO3,uniProtId:Q9Y5L0-2,ncbiNodeId:9606,antigenRange:670-788,antigenLength:923,antigenImageFileName:PA5-58834_TNPO3_Q9Y5L0-2_Rabbit.svg,antigenImageFileNamePDP:PA5-58834_TNPO3_Q9Y5L0-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648795

Product Specific Information

Immunogen sequence: VRCVGKGSAA LLQPLVTQMV NVYHVHQHSC FLYLGSILVD EYGMEEGCRQ GLLDMLQALC IPTFQLLEQQ NGLQNHPDTV DDLFRLATRF IQRSPVTLLR SQVVIPILQW AIASTTLDH

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.