Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (2D12)
Human c-Met 단백질을 인식하는 recombinant rabbit monoclonal antibody로, WB, IHC, ICC/IF, Flow Cytometry, ELISA에 적합. 높은 특이성과 재현성을 제공하며 다양한 암 연구 및 신호전달 분석에 활용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:200 |
| Flow Cytometry (Flow) | 1:20–1:200 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2D12 |
| Immunogen | Synthesized peptide derived from human Met (c-Met) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092454 |
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays a critical role in embryonic development processes including gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, it is involved in wound healing, organ regeneration, and tissue remodeling.
Aberrant MET activity has been associated with cancers including gastric, renal, and breast, making it an important target for cancer therapeutics and diagnostic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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