Thermo Fisher Scientific GNE Recombinant Rabbit Monoclonal Antibody (5T9K10)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5T9K10

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 623-722 of human GNE. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GNE,uniProtId:Q9Y223-1,ncbiNodeId:9606,antigenRange:623-722,antigenLength:722,antigenImageFileName:MA5-55459_GNE_Q9Y223-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55459_GNE_Q9Y223-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: GALHLIQAAK LGNAKAQSIL RTAGTALGLG VVNILHTMNP SLVILSGVLA SHYIHIVKDV IRQQALSSVQ DVDVVVSDLV DPALLGAASM VLDYTTRRIY

Target Information

GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.