Thermo Fisher Scientific GNA13 Recombinant Rabbit Monoclonal Antibody (8M1U0)
GNA13 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot 및 ELISA에 최적화. HEK293 세포 발현, Protein A 정제. 인간, 마우스, 랫트 반응성. -20°C 보관, 반복 동결·해동 피해야 함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8M1U0 |
| Immunogen | Synthetic peptide corresponding to amino acids 278–377 of human GNA13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS (pH 7.3), 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
Product Specific Information
Immunogen Sequence:
NRVFSNVSII LFLNKTDLLE EKVQIVSIKD YFLEFEGDPH CLRDVQKFLV ECFRNKRRDQ QQKPLYHHFT TAINTENIRL VFRDVKDTIL HDNLKQLMLQ
Target Information
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452).
They activate the effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866).
GNA13-dependent Rho signaling regulates transcription factor AP-1 (activating protein-1) and promotes tumor cell invasion and metastasis through the RhoA/ROCK pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452).
It also inhibits CDH1-mediated cell adhesion in a process independent of Rho activation (PubMed:11976333).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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