Thermo Fisher Scientific NRXN3 Polyclonal Antibody
인간 NRXN3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. KLH 결합 합성 펩타이드(436-462 aa)를 면역원으로 사용했으며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 0.26 mg/mL 농도입니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 436–462 amino acids from the C-terminal region of human NRXN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900935 |
Target Information
Neurexins comprise a family of neuronal cell surface proteins, including neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3), and Caspr (neurexin IV).
Neurexins I–III are expressed as α and β isoforms.
- α isoforms: Composed of three cassettes containing two LNS (Laminin A, Neurexins, Sex hormone-binding) domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. They bind to neurexophilins and α-latrotoxin.
- β isoforms: Contain one LNS domain, bind to neuroligins, and play a role in synapse formation and remodeling.
Caspr (Contactin-Associated Protein 1, also known as Paranodin in mouse) contains an extracellular domain similar to other neurexins and binds to the surface glycoprotein Contactin.
Caspr and Caspr2 (a mammalian homolog of Drosophila Neurexin IV) define distinct subdomains in myelinated axons — Caspr at paranodal junctions and Caspr2 with Shaker-like K⁺ channels in the juxtaparanodal region.
Caspr may play a role in glial cell–neuron communication during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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