Thermo Fisher Scientific KChIP3 Polyclonal Antibody
Rabbit polyclonal antibody against human KChIP3 (CSEN/calsenilin/KCNIP3). Validated for WB, ELISA, and IP. Preservative-free liquid form, purified via Protein A and antigen affinity chromatography. Suitable for research use in ion channel and transcrip...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CSEN/calsenilin/KCNIP3 Protein (Met1–Ile256) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788032 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human CSEN/calsenilin/KCNIP3.
Target Information
Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 channels and modulate their function. There are three known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (isoforms a, b, c)
- KChIP3 (calsenilin/DREAM): Expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also binds to regulatory DRE elements, repressing transcription from the c-fos gene. It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator. KChIP3 is also associated with presenilins and implicated in beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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