Thermo Fisher Scientific NGB Polyclonal Antibody
인간 NGB 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P)에서 1:500–1:1,000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(glycerol 포함) 용액 형태로 제공. 뇌 신경세포의 저산소 반응 연구에 적합.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NGB. Recombinant protein control fragment (Product #RP-104263). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644655 |
Product Specific Information
Immunogen sequence:
ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E
Highest antigen sequence identity to the following orthologs:
- Mouse: 93%
- Rat: 95%
Target Information
Globins are a superfamily of gas-binding heme proteins found in bacteria, protists, fungi, plants, and animals. They play roles in oxygen binding, transport, scavenging, detoxification, and sensing.
Neuroglobin (Ngb) is a hexacoordinate hemoglobin predominantly expressed in the vertebrate brain, potentially enhancing oxygen supply to neural tissues. It exhibits high oxygen affinity, and its expression in cerebral neurons suggests a role in neuronal responses to hypoxia or ischemia. In vitro studies show that neuronal hypoxia elevates neuroglobin levels, enhancing neuronal survival.
The human neuroglobin gene maps to chromosome 14q24 and encodes a 151 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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