Thermo Fisher Scientific CACNG1 Polyclonal Antibody
Rabbit polyclonal antibody against human CACNG1, reactive with human, mouse, and rat. Suitable for WB, IHC-P, and ICC/IF. Affinity purified, supplied in PBS with 50% glycerol. Detects endogenous CACNG1, useful for calcium channel and muscle research.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CACNG1 (Accession Q06432), corresponding to amino acid residues L136–C186 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854436 |
Product Specific Information
This antibody detects endogenous levels of total CACNG1.
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release. L-type (long-lasting current) voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2 delta.
The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and membrane trafficking of the alpha1 subunit.
L-type Ca²⁺ channel gamma1 (CACNG1), also known as CACNLG, is a 222 amino acid multi-pass membrane protein of the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, it forms part of the dihydropyridine (DHP)-sensitive calcium channel and may play a role in excitation–contraction coupling.
L-type Ca²⁺ channel gamma1 is also considered a marker for malignant hyperthermia susceptibility (MHS), a dominant skeletal muscle disorder causing hypermetabolic crises triggered by certain anesthetics and depolarizing muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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