Thermo Fisher Scientific TAK1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate TGF-β activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, endothelin, and ephrine.

Through activation of the von Hippel-Lindau tumor suppressor, TAK1 represses PDGF-B, integrin β1, and integrin β5, promoting proper wound healing. TAK1 also plays a key role in IKK activation in pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, leading to TAK1 autophosphorylation and subsequent phosphorylation of IKK-β. Additionally, TAK1 represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.