Thermo Fisher Scientific COPG Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal COPG 항체로, WB, ICC/IF, ELISA에 사용 가능. Affinity Chromatography로 정제된 액상 항체이며, PBS/glycerol buffer에 저장. COPI-coated vesicle 및 Golgi 관련 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 555–874 of human COPG1 (NP_0572121) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.12 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804560 |
Product Specific Information
Immunogen sequence:
IPGLERALQQ YTLEPSEKPF DLKSVPLATA PMAEQRTEST PITAVKQPEK VAATRQEIFQ EQLAAVPEFR GLGPLFKSSP EPVALTESET EYVIRCTKHT FTNHMVFQFD CTNTLNDQTL ENVTVQMEPT EAYEVLCYVP ARSLPYNQPG TCYTLVALPK EDPTAVACTF SCMMKFTVKD CDPTTGETDD EGYEDEYVLE DLEVTVADHI QKVMKLNFEA AWDEVGDEFE KEETFTLSTI KTLEEAVGNI VKFLGMHPCE RSDKVPDNKN THTLLLAGVF RGGHDILVRS RLLLLDTVTM QVTARSLEEL PVDIILASVG
Positive Samples: HepG2, A-375, BT-474, Mouse liver, Mouse kidney, Rat kidney
Cellular Location: COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein
Target Information
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, mediating biosynthetic protein transport from the ER to the trans-Golgi network. It is essential for retrograde Golgi-to-ER transport of dilysine-tagged proteins, maintains Golgi structural integrity, and regulates LDL receptor processing and recycling.
Additionally, the coatomer complex limits lipid storage in lipid droplets and regulates lipid homeostasis by controlling the localization of PLIN2, PLIN3, and PNPLA2 at the lipid droplet surface.
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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